Synopsis: Filmmaker Andrew Stone was always a staunch believer in realism at all costs. Thus it was that much of Highway 301 was lensed on a genuine (and very busy) interstate highway. Based on fact, the film recounts the bloody exploits of the notorious "Tri-State Gang," which preyed upon truck drivers. Gang leader George Legenza (Steve Cochran) will kill anyone who stands in his way--even his own henchmen. Before meeting his well-deserved demise, Legenza leads the authorities on a not-so-merry chase through Virginia, North Carolina and Maryland. A few welcome comic moments are provided by Virginia Grey, playing the soap-opera-fan wife of one of the gang members.